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GENERAL
TITLE
MACROCYCLIC PEPTIDES TDI5575 THAT SELECTIVELY INHIBIT THE MYCOBACTERIUM TUBERCULOSIS PROTEASOME
DATE LAST MODIFIED
26 May 2021
RELEASE
28 Apr 2021
OBSOLETE
CLASSIFICATION
HYDROLASE/HYDROLASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 1 21 1
RESOLUTION RANGE HIGH
2.28
RESOLUTION RANGE LOW
92.97
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.1C00296
LIGANDS
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Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P9WHU1 PRCA, MRA_2124 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS 20S PROTEASOME ALPHA SUBUNIT,PROTEASOME CORE PROTEIN PRCA MYCOBACTERIUM TUBERCULOSIS
20S PROTEASOME ALPHA SUBUNIT,PROTEASOME CORE PROTE ...
Mutations
P9WHU1 PRCA, MRA_2124 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS 20S PROTEASOME ALPHA SUBUNIT,PROTEASOME CORE PROTEIN PRCA MYCOBACTERIUM TUBERCULOSIS
20S PROTEASOME ALPHA SUBUNIT,PROTEASOME CORE PROTE ...
Mutations
P9WHU1 PRCA, MRA_2124 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS 20S PROTEASOME ALPHA SUBUNIT,PROTEASOME CORE PROTEIN PRCA MYCOBACTERIUM TUBERCULOSIS
20S PROTEASOME ALPHA SUBUNIT,PROTEASOME CORE PROTE ...
Mutations
P9WHU1 PRCA, MRA_2124 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS 20S PROTEASOME ALPHA SUBUNIT,PROTEASOME CORE PROTEIN PRCA MYCOBACTERIUM TUBERCULOSIS
20S PROTEASOME ALPHA SUBUNIT,PROTEASOME CORE PROTE ...
Mutations
P9WHU1 PRCA, MRA_2124 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS 20S PROTEASOME ALPHA SUBUNIT,PROTEASOME CORE PROTEIN PRCA MYCOBACTERIUM TUBERCULOSIS
20S PROTEASOME ALPHA SUBUNIT,PROTEASOME CORE PROTE ...
Mutations
P9WHU1 PRCA, MRA_2124 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS 20S PROTEASOME ALPHA SUBUNIT,PROTEASOME CORE PROTEIN PRCA MYCOBACTERIUM TUBERCULOSIS
20S PROTEASOME ALPHA SUBUNIT,PROTEASOME CORE PROTE ...
Mutations
P9WHU1 PRCA, MRA_2124 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS 20S PROTEASOME ALPHA SUBUNIT,PROTEASOME CORE PROTEIN PRCA MYCOBACTERIUM TUBERCULOSIS
20S PROTEASOME ALPHA SUBUNIT,PROTEASOME CORE PROTE ...
Mutations
A5U4D6 PRCB, MRA_2125 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS 20S PROTEASOME BETA SUBUNIT, PROTEASOME CORE PROTEIN PRCB MYCOBACTERIUM TUBERCULOSIS
20S PROTEASOME BETA SUBUNIT, PROTEASOME CORE PROTE ...
Mutations
A5U4D6 PRCB, MRA_2125 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS 20S PROTEASOME BETA SUBUNIT, PROTEASOME CORE PROTEIN PRCB MYCOBACTERIUM TUBERCULOSIS
20S PROTEASOME BETA SUBUNIT, PROTEASOME CORE PROTE ...
Mutations
A5U4D6 PRCB, MRA_2125 ESCHERICHIA COLI BL21(DE3) MYCOBACTERIUM TUBERCULOSIS 20S PROTEASOME BETA SUBUNIT, PROTEASOME CORE PROTEIN PRCB MYCOBACTERIUM TUBERCULOSIS
20S PROTEASOME BETA SUBUNIT, PROTEASOME CORE PROTE ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402