6WNK

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Chain 6WNK_A

Chain 6WNK_B

Chain 6WNK_C

Chain 6WNK_D

Chain 6WNK_E

Chain 6WNK_F

Chain 6WNK_G

Chain 6WNK_H

Chain 6WNK_I

Chain 6WNK_J

Chain 6WNK_K

Chain 6WNK_L

Chain 6WNK_M

Chain 6WNK_N

Chain 6WNK_O

Chain 6WNK_P

Chain 6WNK_Q

Chain 6WNK_R

Chain 6WNK_S

Chain 6WNK_T

Chain 6WNK_U

Chain 6WNK_V

Chain 6WNK_W

Chain 6WNK_X

Chain 6WNK_Y

Chain 6WNK_Z

Chain 6WNK_a

Chain 6WNK_b

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GENERAL

TITLE

MACROCYCLIC PEPTIDES TDI5575 THAT SELECTIVELY INHIBIT THE MYCOBACTERIUM TUBERCULOSIS PROTEASOME

DATE LAST MODIFIED

26 May 2021

RELEASE

28 Apr 2021

OBSOLETE

CLASSIFICATION

HYDROLASE/HYDROLASE INHIBITOR

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 1 21 1

RESOLUTION RANGE HIGH

2.28

RESOLUTION RANGE LOW

92.97

PUBMED ID

33949190

DOI

10.1021/ACS.JMEDCHEM.1C00296

PDBe

6WNK

LIGANDS

Chains

Target Protein	Gene	Expression System	Organism	Synonims	Actions
P08134	PRCA, MRA_2124	ESCHERICHIA COLI BL21(DE3)	MYCOBACTERIUM TUBERCULOSIS	20S PROTEASOME ALPHA SUBUNIT,PROTEASOME CORE PROTE ...
A5U4D5	PRCA, MRA_2124	ESCHERICHIA COLI BL21(DE3)	MYCOBACTERIUM TUBERCULOSIS	20S PROTEASOME ALPHA SUBUNIT,PROTEASOME CORE PROTE ...
P11838	PRCA, MRA_2124	ESCHERICHIA COLI BL21(DE3)	MYCOBACTERIUM TUBERCULOSIS	20S PROTEASOME ALPHA SUBUNIT,PROTEASOME CORE PROTE ...
A5U4D5	PRCA, MRA_2124	ESCHERICHIA COLI BL21(DE3)	MYCOBACTERIUM TUBERCULOSIS	20S PROTEASOME ALPHA SUBUNIT,PROTEASOME CORE PROTE ...
P09874	PRCA, MRA_2124	ESCHERICHIA COLI BL21(DE3)	MYCOBACTERIUM TUBERCULOSIS	20S PROTEASOME ALPHA SUBUNIT,PROTEASOME CORE PROTE ...
A5U4D5	PRCA, MRA_2124	ESCHERICHIA COLI BL21(DE3)	MYCOBACTERIUM TUBERCULOSIS	20S PROTEASOME ALPHA SUBUNIT,PROTEASOME CORE PROTE ...
A5U4D5	PRCA, MRA_2124	ESCHERICHIA COLI BL21(DE3)	MYCOBACTERIUM TUBERCULOSIS	20S PROTEASOME ALPHA SUBUNIT,PROTEASOME CORE PROTE ...
P0A884	PRCB, MRA_2125	ESCHERICHIA COLI BL21(DE3)	MYCOBACTERIUM TUBERCULOSIS	20S PROTEASOME BETA SUBUNIT, PROTEASOME CORE PROTE ...
A5U4D6	PRCB, MRA_2125	ESCHERICHIA COLI BL21(DE3)	MYCOBACTERIUM TUBERCULOSIS	20S PROTEASOME BETA SUBUNIT, PROTEASOME CORE PROTE ...	Mutations
A5U4D6	PRCB, MRA_2125	ESCHERICHIA COLI BL21(DE3)	MYCOBACTERIUM TUBERCULOSIS	20S PROTEASOME BETA SUBUNIT, PROTEASOME CORE PROTE ...	Mutations

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402