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GENERAL
TITLE
STRUCTURE OF HUMAN SHP2 IN COMPLEX WITH INHIBITOR IACS-13909
DATE LAST MODIFIED
-
RELEASE
17 Mar 2021
OBSOLETE
CLASSIFICATION
HYDROLASE/HYDROLASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
2.4
RESOLUTION RANGE LOW
42.13
PUBMED ID
DOI
10.1158/0008-5472.CAN-20-1634
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
Q06124 PTPN11, PTP2C, SHPTP2 ESCHERICHIA COLI HUMAN PROTEIN-TYROSINE PHOSPHATASE 1D,PTP-1D,PROTEIN-TYROSINEPHOSPHATASE 2C,PTP-2C,SH-PTP2,SHP2,SH-PTP3 HUMAN
PROTEIN-TYROSINE PHOSPHATASE 1D,PTP-1D,PROTEIN-TYR ...
Mutations
Q06124 PTPN11, PTP2C, SHPTP2 ESCHERICHIA COLI HUMAN PROTEIN-TYROSINE PHOSPHATASE 1D,PTP-1D,PROTEIN-TYROSINEPHOSPHATASE 2C,PTP-2C,SH-PTP2,SHP2,SH-PTP3 HUMAN
PROTEIN-TYROSINE PHOSPHATASE 1D,PTP-1D,PROTEIN-TYR ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402