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GENERAL
TITLE
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (Y181C) VARIANT IN COMPLEX WITH 7-(2-(2-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL) ETHOXY)PHENOXY)-2-NAPHTHONITRILE (JLJ649), A NON-NUCLEOSIDE INHIBITOR
DATE LAST MODIFIED
16 Dec 2020
RELEASE
22 Jul 2020
OBSOLETE
CLASSIFICATION
TRANSFERASE, HYDROLASE/INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 1 2 1
RESOLUTION RANGE HIGH
2.745
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1002/PRO.3910
PDBe
6X49
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonyms | Actions | ||
|---|---|---|---|---|---|---|---|---|
| P03366 | GAG-POL | ESCHERICHIA COLI BL21(DE3) | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 GROUP M | P66 RT | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 GROUP M | P66 RT | Mutations | |
| P03366 | GAG-POL | ESCHERICHIA COLI BL21(DE3) | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 GROUP M | -- | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 GROUP M | -- | Mutations |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402