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GENERAL
TITLE
HUMAN CYCLOPHILIN A BOUND TO A SERIES OF ACYLCIC AND MACROCYCLIC INHIBITORS: (2R,5S,11S,14S,18E)-14-CYCLOBUTYL-2,11,17,17-TETRAMETHYL- 15-OXA-3,9,12,26,29-PENTAAZATETRACYCLO[18.5.3.1~5,9~.0~23, 27~]NONACOSA-1(25),18,20(28),21,23,26-HEXAENE-4,10,13,16-TETRONE (COMPOUND 33)
DATE LAST MODIFIED
26 Aug 2020
RELEASE
24 Jun 2020
OBSOLETE
CLASSIFICATION
ISOMERASE/ISOMERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
1.8
RESOLUTION RANGE LOW
34.04
PUBMED ID
DOI
10.1021/ACS.JCIM.0C00132
PDBe
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LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P62937 PPIA, CYPA ESCHERICHIA COLI HUMAN PPIASE A,CYCLOPHILIN A,CYCLOSPORIN A-BINDING PROTEIN,ROTAMASE A HUMAN
PPIASE A,CYCLOPHILIN A,CYCLOSPORIN A-BINDING PROTE ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402