6XIH

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Chain 6XIH_A

Chain 6XIH_B

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GENERAL

TITLE

STRUCTURE-GUIDED OPTIMIZATION OF A NOVEL CLASS OF ASK1 INHIBITORS WITH INCREASED SP3 CHARACTER AND AN EXQUISITE SELECTIVITY PROFILE

DATE LAST MODIFIED

RELEASE

12 Aug 2020

OBSOLETE

CLASSIFICATION

METAL BINDING PROTEIN

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 65 2 2

RESOLUTION RANGE HIGH

2.63

RESOLUTION RANGE LOW

PUBMED ID

DOI

10.1016/J.BMCL.2020.127405

PDBe

LIGANDS

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	Q99683	MAP3K5, ASK1, MAPKKK5, MEKK5	ESCHERICHIA COLI	HUMAN	APOPTOSIS SIGNAL-REGULATING KINASE 1,ASK-1,MAPK/ER ...	Mutations
	Q99683	MAP3K5, ASK1, MAPKKK5, MEKK5	ESCHERICHIA COLI	HUMAN	APOPTOSIS SIGNAL-REGULATING KINASE 1,ASK-1,MAPK/ER ...	Mutations

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402