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6YK2

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GENERAL
TITLE
STRUCTURE OF THE AMPA RECEPTOR GLUA2O LIGAND-BINDING DOMAIN (S1S2J) IN COMPLEX WITH THE COMPOUND (S)-1-[2'-AMINO-2'-CARBOXYETHYL]-5,7- DIHYDROTHIENO[3,4-D]PYRIMIDIN- 2,4(1H,3H)-DIONE AT RESOLUTION 1.60A
DATE LAST MODIFIED
1 Jul 2020
RELEASE
3 Jun 2020
OBSOLETE
CLASSIFICATION
MEMBRANE PROTEIN
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 2
RESOLUTION RANGE HIGH
1.61
RESOLUTION RANGE LOW
37.424
PUBMED ID
DOI
10.1021/ACSCHEMNEURO.0C00195

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P19491 GRIA2, GLUR2 ESCHERICHIA COLI BL21(DE3) RAT GLUR-2,AMPA-SELECTIVE GLUTAMATE RECEPTOR 2,GLUR-B,GLUR-K2,GLUTAMATE RECEPTOR IONOTROPIC,AMPA 2,GLUA2BINDING DOMAIN OF GLUA2O. TRANSMEMBRANE REGIONS WERE GENETICALLYREMOVED AND REPLACED WITH A GLY-THR LINKER (RESIDUE 118-119). THESEQUENCE MATCHES DISCONTINOUSLY WITH THE REFERENCE DATABASE (UNPRESIDUES 413-527 AND 653-797, NUMBERING WITH SIGNAL PEPTIDE OF 21AMINO ACIDS). THE TWO FIRST RESIDUES (GLY, ALA) ARE CLONING REMNANTS. RAT
GLUR-2,AMPA-SELECTIVE GLUTAMATE RECEPTOR 2,GLUR-B, ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402