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3D Structure View

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GENERAL
TITLE
FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-METHYL-N-{3- [(2-PHENYLAMINO-5-TRIFLUOROMETHYL-PYRIMIDIN-4-YLAMINO)-METHYL]- PYRIDIN-2-YL}-METHANESULFONAMIDE
DATE LAST MODIFIED
2 Jun 2021
RELEASE
10 Feb 2021
OBSOLETE
CLASSIFICATION
TRANSFERASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 1 2 1
RESOLUTION RANGE HIGH
2.298
RESOLUTION RANGE LOW
171.52
PUBMED ID
DOI
10.1016/J.CHEMBIOL.2021.01.003
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
Q05397 PTK2, FAK, FAK1 TRICHOPLUSIA NI HUMAN FADK 1,FOCAL ADHESION KINASE-RELATED NONKINASE,FRNK,PROTEINPHOSPHATASE 1 REGULATORY SUBUNIT 71,PPP1R71,PROTEIN-TYROSINE KINASE2,P125FAK,PP125FAK HUMAN
FADK 1,FOCAL ADHESION KINASE-RELATED NONKINASE,FRN ...
Mutations
Q05397 PTK2, FAK, FAK1 TRICHOPLUSIA NI HUMAN FADK 1,FOCAL ADHESION KINASE-RELATED NONKINASE,FRNK,PROTEINPHOSPHATASE 1 REGULATORY SUBUNIT 71,PPP1R71,PROTEIN-TYROSINE KINASE2,P125FAK,PP125FAK HUMAN
FADK 1,FOCAL ADHESION KINASE-RELATED NONKINASE,FRN ...
Mutations
Q05397 PTK2, FAK, FAK1 TRICHOPLUSIA NI HUMAN FADK 1,FOCAL ADHESION KINASE-RELATED NONKINASE,FRNK,PROTEINPHOSPHATASE 1 REGULATORY SUBUNIT 71,PPP1R71,PROTEIN-TYROSINE KINASE2,P125FAK,PP125FAK HUMAN
FADK 1,FOCAL ADHESION KINASE-RELATED NONKINASE,FRN ...
Mutations
Q05397 PTK2, FAK, FAK1 TRICHOPLUSIA NI HUMAN FADK 1,FOCAL ADHESION KINASE-RELATED NONKINASE,FRNK,PROTEINPHOSPHATASE 1 REGULATORY SUBUNIT 71,PPP1R71,PROTEIN-TYROSINE KINASE2,P125FAK,PP125FAK HUMAN
FADK 1,FOCAL ADHESION KINASE-RELATED NONKINASE,FRN ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402