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GENERAL
TITLE
HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) IN COMPLEX WITH TERT-BUTYL 6-(5- HYDROXY-4-(1H-1,2,3-TRIAZOL-1-YL)-1H-PYRAZOL-1-YL)NICOTINATE (IOX4)
DATE LAST MODIFIED
8 Dec 2021
RELEASE
7 Apr 2021
OBSOLETE
CLASSIFICATION
OXIDOREDUCTASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 1 21 1
RESOLUTION RANGE HIGH
2.01
RESOLUTION RANGE LOW
76.76
PUBMED ID
DOI
10.1002/CMDC.202100133
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
Q9GZT9 EGLN1, C1ORF12, PNAS-118, PNAS-137 ESCHERICHIA COLI BL21(DE3) HUMAN HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE 2,HIF-PH2,HIF-PROLYL HYDROXYLASE 2,HPH-2,PROLYL HYDROXYLASE DOMAIN-CONTAININGPROTEIN 2,PHD2,SM-20 HUMAN
HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE 2,HIF- ...
Mutations
Q9GZT9 EGLN1, C1ORF12, PNAS-118, PNAS-137 ESCHERICHIA COLI BL21(DE3) HUMAN HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE 2,HIF-PH2,HIF-PROLYL HYDROXYLASE 2,HPH-2,PROLYL HYDROXYLASE DOMAIN-CONTAININGPROTEIN 2,PHD2,SM-20 HUMAN
HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE 2,HIF- ...
Mutations
Q9GZT9 EGLN1, C1ORF12, PNAS-118, PNAS-137 ESCHERICHIA COLI BL21(DE3) HUMAN HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE 2,HIF-PH2,HIF-PROLYL HYDROXYLASE 2,HPH-2,PROLYL HYDROXYLASE DOMAIN-CONTAININGPROTEIN 2,PHD2,SM-20 HUMAN
HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE 2,HIF- ...
Mutations
Q9GZT9 EGLN1, C1ORF12, PNAS-118, PNAS-137 ESCHERICHIA COLI BL21(DE3) HUMAN HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE 2,HIF-PH2,HIF-PROLYL HYDROXYLASE 2,HPH-2,PROLYL HYDROXYLASE DOMAIN-CONTAININGPROTEIN 2,PHD2,SM-20 HUMAN
HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE 2,HIF- ...
Mutations
Q9GZT9 EGLN1, C1ORF12, PNAS-118, PNAS-137 ESCHERICHIA COLI BL21(DE3) HUMAN HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE 2,HIF-PH2,HIF-PROLYL HYDROXYLASE 2,HPH-2,PROLYL HYDROXYLASE DOMAIN-CONTAININGPROTEIN 2,PHD2,SM-20 HUMAN
HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE 2,HIF- ...
Mutations
Q9GZT9 EGLN1, C1ORF12, PNAS-118, PNAS-137 ESCHERICHIA COLI BL21(DE3) HUMAN HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE 2,HIF-PH2,HIF-PROLYL HYDROXYLASE 2,HPH-2,PROLYL HYDROXYLASE DOMAIN-CONTAININGPROTEIN 2,PHD2,SM-20 HUMAN
HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE 2,HIF- ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402