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GENERAL
TITLE
STRUCTURAL BASIS OF REACTIVATION OF ONCOGENIC P53 MUTANTS BY A SMALL MOLECULE: METHYLENE QUINUCLIDINONE (MQ). HUMAN P53DBD-R273C/S240R DOUBLE MUTANT BOUND TO DNA AND MQ: R273C/S240R-DNA-MQ
DATE LAST MODIFIED
15 Dec 2021
RELEASE
8 Dec 2021
OBSOLETE
CLASSIFICATION
TRANSCRIPTION
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 1 2 1
RESOLUTION RANGE HIGH
1.85
RESOLUTION RANGE LOW
25
PUBMED ID
DOI
10.1038/S41467-021-27142-6
PDBe
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LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P04637 TP53, P53 ESCHERICHIA COLI BL21(DE3) HUMAN ANTIGEN NY-CO-13,PHOSPHOPROTEIN P53,TUMOR SUPPRESSOR P53 HUMAN
ANTIGEN NY-CO-13,PHOSPHOPROTEIN P53,TUMOR SUPPRESS ...
Mutations
-- -- SYNTHETIC CONSTRUCT -- SYNTHETIC CONSTRUCT --
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402