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GENERAL
TITLE
UBIQUITIN LIGATION TO F-BOX PROTEIN SUBSTRATES BY SCF-RBR E3-E3 SUPER- ASSEMBLY: NEDD8-CUL1-RBX1-SKP1-SKP2-CKSHS1-CYCLIN A-CDK2-P27- UBE2L3~UB~ARIH1. TRANSITION STATE 1
DATE LAST MODIFIED
10 Mar 2021
RELEASE
10 Feb 2021
OBSOLETE
CLASSIFICATION
LIGASE
EXPERIMENT TYPE
ELECTRON MICROSCOPY
SPACE GROUP
P 1
RESOLUTION RANGE HIGH
3.8
RESOLUTION RANGE LOW
3.8
PUBMED ID
DOI
10.1038/S41586-021-03197-9
PDBe
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LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
Q13616 CUL1 TRICHOPLUSIA NI HUMAN CUL-1 HUMAN
CUL-1
Mutations
A0A1B0GUS4 UBE2L3, UBCE7, UBCH7 ESCHERICHIA COLI HUMAN E2 UBIQUITIN-CONJUGATING ENZYME L3,L-UBC,UBCH7,UBIQUITINCARRIER PROTEIN L3,UBIQUITIN-CONJUGATING ENZYME E2-F1,UBIQUITIN-PROTEIN LIGASE L3 HUMAN
E2 UBIQUITIN-CONJUGATING ENZYME L3,L-UBC,UBCH7,UBI ...
Q9Y4X5 ARIH1, ARI, MOP6, UBCH7BP, HUSSY-27 ESCHERICHIA COLI HUMAN H7-AP2,HHARI,MONOCYTE PROTEIN 6,MOP-6,PROTEIN ARIADNE-1HOMOLOG,ARI-1,UBCH7-BINDING PROTEIN,UBCM4-INTERACTING PROTEIN,UBIQUITIN-CONJUGATING ENZYME E2-BINDING PROTEIN 1 HUMAN
H7-AP2,HHARI,MONOCYTE PROTEIN 6,MOP-6,PROTEIN ARIA ...
Mutations
P61024 CKS1B, CKS1, PNAS-143, PNAS-16 ESCHERICHIA COLI HUMAN CKS-1 HUMAN
CKS-1
Mutations
P24941 CDK2, CDKN2 ESCHERICHIA COLI HUMAN CELL DIVISION PROTEIN KINASE 2,P33 PROTEIN KINASE HUMAN
CELL DIVISION PROTEIN KINASE 2,P33 PROTEIN KINASE
Mutations
Q15843 NEDD8 ESCHERICHIA COLI HUMAN NEDDYLIN,NEURAL PRECURSOR CELL EXPRESSED DEVELOPMENTALLYDOWN-REGULATED PROTEIN 8,NEDD-8,UBIQUITIN-LIKE PROTEIN NEDD8 HUMAN
NEDDYLIN,NEURAL PRECURSOR CELL EXPRESSED DEVELOPME ...
Mutations
P46527 CDKN1B, KIP1 ESCHERICHIA COLI HUMAN CYCLIN-DEPENDENT KINASE INHIBITOR P27,P27KIP1 HUMAN
CYCLIN-DEPENDENT KINASE INHIBITOR P27,P27KIP1
Mutations
P62877 RBX1, RNF75, ROC1 TRICHOPLUSIA NI HUMAN E3 UBIQUITIN-PROTEIN TRANSFERASE RBX1,PROTEIN ZYP,RINGFINGER PROTEIN 75,RING-BOX PROTEIN 1,RBX1,REGULATOR OF CULLINS 1,ROC1 HUMAN
E3 UBIQUITIN-PROTEIN TRANSFERASE RBX1,PROTEIN ZYP, ...
Mutations
P63208 SKP1, EMC19, OCP2, SKP1A, TCEB1L ESCHERICHIA COLI HUMAN CYCLIN-A/CDK2-ASSOCIATED PROTEIN P19,P19A,ORGAN OF CORTIPROTEIN 2,OCP-2,ORGAN OF CORTI PROTEIN II,OCP-II,RNA POLYMERASE IIELONGATION FACTOR-LIKE PROTEIN,SIII,TRANSCRIPTION ELONGATION FACTOR BPOLYPEPTIDE 1-LIKE,P19SKP1 HUMAN
CYCLIN-A/CDK2-ASSOCIATED PROTEIN P19,P19A,ORGAN OF ...
Mutations
Q13309 SKP2, FBXL1 ESCHERICHIA COLI HUMAN CYCLIN-A/CDK2-ASSOCIATED PROTEIN P45,F-BOX PROTEIN SKP2,F-BOX/LRR-REPEAT PROTEIN 1,P45SKP2 HUMAN
CYCLIN-A/CDK2-ASSOCIATED PROTEIN P45,F-BOX PROTEIN ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402