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GENERAL
TITLE
UBIQUITIN LIGATION TO F-BOX PROTEIN SUBSTRATES BY SCF-RBR E3-E3 SUPER- ASSEMBLY: CUL1-RBX1-SKP1-SKP2-CKSHS1-P27~UB~ARIH1. TRANSITION STATE 2
DATE LAST MODIFIED
10 Mar 2021
RELEASE
17 Feb 2021
OBSOLETE
CLASSIFICATION
LIGASE
EXPERIMENT TYPE
ELECTRON MICROSCOPY
SPACE GROUP
P 1
RESOLUTION RANGE HIGH
3.91
RESOLUTION RANGE LOW
3.91
PUBMED ID
DOI
10.1038/S41586-021-03197-9
PDBe
--
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonims | Actions |
|---|---|---|---|---|---|---|
| Q13616 | CUL1 | TRICHOPLUSIA NI | HUMAN | CUL-1 | Mutations | |
| Q9Y4X5 | ARIH1, ARI, MOP6, UBCH7BP, HUSSY-27 | ESCHERICHIA COLI | HUMAN | H7-AP2,HHARI,MONOCYTE PROTEIN 6,MOP-6,PROTEIN ARIA ... | Mutations | |
| P61024 | CKS1B, CKS1, PNAS-143, PNAS-16 | ESCHERICHIA COLI | HUMAN | CKS-1 | Mutations | |
| P46527 | CDKN1B, KIP1 | SYNTHETIC CONSTRUCT | HUMAN | CYCLIN-DEPENDENT KINASE INHIBITOR P27,P27KIP1 | Mutations | |
| P62877 | RBX1, RNF75, ROC1 | TRICHOPLUSIA NI | HUMAN | E3 UBIQUITIN-PROTEIN TRANSFERASE RBX1,PROTEIN ZYP, ... | Mutations | |
| P63208 | SKP1, EMC19, OCP2, SKP1A, TCEB1L | ESCHERICHIA COLI | HUMAN | CYCLIN-A/CDK2-ASSOCIATED PROTEIN P19,P19A,ORGAN OF ... | Mutations | |
| Q13309 | SKP2, FBXL1 | ESCHERICHIA COLI | HUMAN | CYCLIN-A/CDK2-ASSOCIATED PROTEIN P45,F-BOX PROTEIN ... | Mutations | |
| P0CG48 | UBC | ESCHERICHIA COLI | HUMAN | -- | Mutations |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402