7C9I

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Bioassembly 7C9I_1

Chain 7C9I_A

Chain 7C9I_B

Chain 7C9I_C

Chain 7C9I_D

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GENERAL

TITLE

HUMAN GAMMA-SECRETASE IN COMPLEX WITH SMALL MOLECULE L-685,458

DATE LAST MODIFIED

3 Feb 2021

RELEASE

27 Jan 2021

OBSOLETE

CLASSIFICATION

HYDROLASE

EXPERIMENT TYPE

ELECTRON MICROSCOPY

SPACE GROUP

P 1

RESOLUTION RANGE HIGH

3.1

RESOLUTION RANGE LOW

3.1

PUBMED ID

DOI

10.1016/J.CELL.2020.11.049

PDBe

LIGANDS

Target Protein	Gene	Expression System	Organism	Synonims	Actions
Q92542	NCSTN, KIAA0253, UNQ1874/PRO4317	HOMO SAPIENS	HUMAN	--	Mutations
P37019	PSEN1, AD3, PS1, PSNL1, KIAA0253	HOMO SAPIENS	HUMAN	PS-1,PROTEIN S182
O95696	APH1A, PSF, CGI-78, UNQ579/PRO1141,UNQ1874/PRO4317	HOMO SAPIENS	HUMAN	APH-1A,APH-1ALPHA,PRESENILIN-STABILIZATION FACTOR
O95696	PSENEN, PEN2, MDS033	HOMO SAPIENS	HUMAN	PRESENILIN ENHANCER PROTEIN 2

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402