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GENERAL
TITLE
CRYSTAL STRUCTURE OF THE BRAF:MEK1 KINASES IN COMPLEX WITH AMPPNP AND SELUMETINIB
DATE LAST MODIFIED
10 Nov 2021
RELEASE
21 Apr 2021
OBSOLETE
CLASSIFICATION
TRANSFERASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 31 2 1
RESOLUTION RANGE HIGH
3.19
RESOLUTION RANGE LOW
43.44
PUBMED ID
DOI
10.1073/PNAS.2107207118
PDBe
7M0T
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonims | Actions |
|---|---|---|---|---|---|---|
| P15056 | BRAF, BRAF1, RAFB1 | SPODOPTERA FRUGIPERDA | HUMAN | PROTO-ONCOGENE B-RAF,P94,V-RAF MURINE SARCOMA VIRA ... | Mutations | |
| Q02750 | MAP2K1, MEK1, PRKMK1 | SPODOPTERA FRUGIPERDA | HUMAN | MKK1,ERK ACTIVATOR KINASE 1,MAPK/ERK KINASE 1,MEK ... | Mutations |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402