7M0V

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Bioassembly 7M0V_1

Chain 7M0V_A

Chain 7M0V_B

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GENERAL

TITLE

CRYSTAL STRUCTURE OF THE BRAF:MEK1 KINASES IN COMPLEX WITH AMPPNP AND COBIMETINIB

DATE LAST MODIFIED

10 Nov 2021

RELEASE

21 Apr 2021

OBSOLETE

CLASSIFICATION

TRANSFERASE

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 31 2 1

RESOLUTION RANGE HIGH

3.16

RESOLUTION RANGE LOW

43.3

PUBMED ID

DOI

10.1073/PNAS.2107207118

PDBe

LIGANDS

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	Q9UIF8	BRAF, BRAF1, RAFB1	SPODOPTERA FRUGIPERDA	HUMAN	PROTO-ONCOGENE B-RAF,P94,V-RAF MURINE SARCOMA VIRA ...
	Q02750	MAP2K1, MEK1, PRKMK1	SPODOPTERA FRUGIPERDA	HUMAN	MKK1,ERK ACTIVATOR KINASE 1,MAPK/ERK KINASE 1,MEK ...	Mutations

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402