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GENERAL
TITLE
CRYO-EM STRUCTURE OF THE NON-ACYLATED TIRZEPATIDE (LY3298176)-BOUND HUMAN GLP-1R-GS COMPLEX
DATE LAST MODIFIED
16 Mar 2022
RELEASE
2 Mar 2022
OBSOLETE
CLASSIFICATION
STRUCTURAL PROTEIN
EXPERIMENT TYPE
ELECTRON MICROSCOPY
SPACE GROUP
P 1
RESOLUTION RANGE HIGH
3
RESOLUTION RANGE LOW
3
PUBMED ID
DOI
10.1038/S41467-022-28683-0
PDBe
--
LIGANDS
--

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P63092 GNAS, GNAS1, GSP SPODOPTERA FRUGIPERDA HUMAN ADENYLATE CYCLASE-STIMULATING G ALPHA PROTEIN HUMAN
ADENYLATE CYCLASE-STIMULATING G ALPHA PROTEIN
Mutations
P54311 GNB1 SPODOPTERA FRUGIPERDA RAT TRANSDUCIN BETA CHAIN 1 RAT
TRANSDUCIN BETA CHAIN 1
Mutations
P59768 GNG2 SPODOPTERA FRUGIPERDA BOVINE G GAMMA-I BOVINE
G GAMMA-I
-- ESCHERICHIA COLI ESCHERICHIA COLI -- ESCHERICHIA COLI --
-- -- HOMO SAPIENS -- HOMO SAPIENS --
P43220 GLP1R SPODOPTERA FRUGIPERDA HUMAN GLP-1 RECEPTOR,GLP-1-R,GLP-1R HUMAN
GLP-1 RECEPTOR,GLP-1-R,GLP-1R
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402