FEATURES

FAMILY

DESCRIPTION

Also known as INS1B_CONGE, INS1B. This venom insulin, from a fish-hunting cone snail, facilitates prey capture by rapidly inducing hypoglycemic shock. It is one of the smallest known insulin found in nature and lacks the C-terminal segment of the B chain that, in human insulin, mediates engagement of the insulin receptor and assembly of the hormone's hexameric storage form. Despite lacking this segment, it both binds and activates human insulin receptor (long isoform (HIR-B)) with only a 10-fold lower potency. In vivo, intraperitoneal injection of this peptide into zebrafish lowers blood glucose with the same potency than human insulin. In addition, when applied to water, this peptide reduces overall locomotor activity of zebrafish larvae, observed as a significant decrease in the percentage of time spent swimming and movement frequency. Heterodimer of A and B chains; disulfide-linked.

EXTERNAL LINKS

INS1B

Mutations

Mutation(s) distribution

Mutations table