FEATURES

FAMILY

DESCRIPTION

Also known as TRPM2_DANRE, trpm2. Nonselective, voltage-independent cation channel that mediates Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as ligand-gated ion channel. Binding of ADP-ribose to the cytoplasmic N-terminal region causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening. Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification

trpm2

Transient receptor potential cation channel subfamily M member 2

Structural Ligandability

Domains Chains

0 chains assessed

trpm2

Structural Ligandability

Domains Chains

Distribution