FEATURES

FAMILY

DESCRIPTION

Also known as HSTX1_HAESL, HSTX1. Leech salivary gland peptide with unknown function (PubMed:32524995). It was originally described as exhibiting analgesic function by specifically inhibiting rodent Nav1.8/SCN10A and Nav1.9/SCN11A voltage-gated sodium channels, as well as showing analgesic activities in several mouse models (PubMed:29559913). In a second study, the synthetic peptide has been shown as having very weak activity on Nav1.8/SCN10A at the highest concentration tested (90 uM) and as being only very modestly active at hNav1.9/SCN11A, with a modest peak current size reduction (~19%) at high concentrations (10 uM) (PubMed:32524995). In addition, this second study reports no analgesic activity in a mouse model of inflammatory pain (PubMed:32524995).

EXTERNAL LINKS

HSTX1

Peptide HSTX-I

HSTX1

Molecular Synopsis