FEATURES

FAMILY

DESCRIPTION

Also known as DOP_ACIC1, dop. Displays depupylase (DPUP) activity, removing conjugated Pup from target proteins; is thus involved in the recycling of Pup and may function similarly to deubiquitinases (DUBs) in eukaryotes to prevent or promote proteasomal degradation of certain proteins. Is also able to catalyze the deamidation of the C-terminal glutamine to glutamate in a variant of the prokaryotic ubiquitin-like protein Pup; however, since Pup from A.cellulolyticus possesses a C-terminal glutamate, this deamidase activity may be of no significance in vivo. Likely interacts with the C-terminal half of the prokaryotic ubiquitin-like protein Pup.

EXTERNAL LINKS

uniprot
enzyme classification

dop

Depupylase

dop

Molecular Synopsis