FEATURES

FAMILY

resistance-nodulation-cell division (RND) (TC 2.A.6) family

DESCRIPTION

Also known as MMPL3_MYCS2, mmpL3. Transports trehalose monomycolate (TMM) to the cell wall (PubMed:31239378, PubMed:22520756, PubMed:28698380). Flips TMM across the inner membrane. Membrane potential is not required for this function (PubMed:28698380). Transports probably phosphatidylethanolamine (PE) as well. Binds specifically both TMM and PE, but not trehalose dimycolate (TDM). Binds also diacylglycerol (DAG) and other phospholipids, including phosphatidylglycerol (PG), phosphatidylinositol (PI), and cardiolipin (CDL) (PubMed:31113875). Contributes to membrane potential, cell wall composition, antibiotic susceptibility and fitness (PubMed:28703701). Monomer (PubMed:30682372, PubMed:31113875). Interacts with TtfA (via N-terminus); active trehalose monomycolate (TMM) biosynthesis is not required for the complex formation. Interacts with MSMEG_5308 (PubMed:31239378).

EXTERNAL LINKS

mmpL3

Trehalose monomycolate exporter MmpL3

mmpL3

Molecular Synopsis