FEATURES

FAMILY

DESCRIPTION

Also known as PIMA_MYCS2, pimA. Involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM). Catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1, 2-linked mannose residue (PIM1) (PubMed:12068013, PubMed:19638342, PubMed:19520856). In contrary to PimB, the mannosyltransferase PimA is unable to transfer a mannose residue to the position 6 of the phosphatidyl-myo-inositol of PIM1 (PubMed:19638342). Monomer.

EXTERNAL LINKS

pimA

Mutations

Mutation(s) distribution

Mutations table