FEATURES

FAMILY

DESCRIPTION

Also known as CP142_MYCS2, cyp142, cyp142A2. Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one.

EXTERNAL LINKS

uniprot
enzyme classification

cyp142

Steroid C26-monooxygenase

cyp142

Molecular Synopsis