FEATURES

FAMILY

DESCRIPTION

Also known as IRGM_HUMAN, IRGM, IFI1, IRGM1, LRG47. Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

IRGM

Immunity-related GTPase family M protein

IRGM

Molecular Synopsis