FEATURES

FAMILY

DESCRIPTION

Also known as CCR4_ASPNC, ccr4. Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

ccr4

CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

ccr4

Structural Ligandability

Domains Chains

Distribution