FEATURES

FAMILY

DESCRIPTION

Also known as IF4A_ASPNC, tif1, tif41. ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

tif1

ATP-dependent RNA helicase eIF4A

tif1

Structural Ligandability

Domains Chains

Distribution