FEATURES

FAMILY

DESCRIPTION

Also known as PRP28_ASPNC, prp28. ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity). Component of the U5 snRNP complex.

EXTERNAL LINKS

uniprot
enzyme classification

prp28

Pre-mRNA-splicing ATP-dependent RNA helicase prp28

prp28

Structural Ligandability

Domains Chains

Distribution