FEATURES

FAMILY

DESCRIPTION

Also known as PEPA_ASPNC, pepA. Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions, but also accepts a lysine residue in the P1 position, leading to the activation of trypsinogen and chymotrypsinogen A. Monomer.

EXTERNAL LINKS

uniprot
enzyme classification

pepA

Aspergillopepsin-1

pepA

Molecular Synopsis