FEATURES

FAMILY

DESCRIPTION

Also known as TYW5_HUMAN, TYW5, C2orf60. tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TYW5

tRNA wybutosine-synthesizing protein 5

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

TYW5

Structural Ligandability

Domains Chains

Distribution