FEATURES

FAMILY

DESCRIPTION

Also known as MSX2_PANTR, MSX2. Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

MSX2

Homeobox protein MSX-2

MSX2

Molecular Synopsis