FEATURES

FAMILY

DESCRIPTION

Also known as DTD_STRSV, dtd. An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

dtd

D-aminoacyl-tRNA deacylase

Mutations

Mutation(s) distribution

Mutations table

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