FEATURES

FAMILY

DESCRIPTION

Also known as DPHB_METMJ, dphB. S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

dphB

Diphthine synthase

dphB

Molecular Synopsis