FEATURES

FAMILY

tRNA nucleotidyltransferase/poly(A) polymerase family

DESCRIPTION

Also known as CCA_ACIBT, cca. Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2', 3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. Monomer. Can also form homodimers and oligomers.

EXTERNAL LINKS

uniprot
enzyme classification

cca

Multifunctional CCA protein

cca

Structural Ligandability

Domains Chains

Distribution