FEATURES

FAMILY

GEF (guanine exchange factor) SopE family

DESCRIPTION

Also known as BOPE_BURP6, bopE. Activator for both CDC42 and RAC1 by directly interacting with these Rho GTPases and acting as a guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, thus promoting bacterial entry into non-phagocytic cells (By similarity). Monomer. Interacts with human CDC42 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

bopE

Guanine nucleotide exchange factor BopE

bopE

Structural Ligandability

Domains Chains

Distribution