bopE (Guanine nucleotide exchange factor BopE)

FEATURES

ORGANISM

Burkholderia pseudomallei (strain 668)

FAMILY

GEF (guanine exchange factor) SopE family

DESCRIPTION

Also known as BOPE_BURP6, bopE. Activator for both CDC42 and RAC1 by directly interacting with these Rho GTPases and acting as a guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, thus promoting bacterial entry into non-phagocytic cells (By similarity). Monomer. Interacts with human CDC42 (By similarity).

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EXTERNAL LINKS

bopE

Guanine nucleotide exchange factor BopE

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

bopE

Molecular Synopsis