FEATURES

FAMILY

DESCRIPTION

Also known as HAP2_CHLRE, HAP2, GCS1. During fertilization, required on male (minus) gametes for their fusion with female (plus) gametes (PubMed:18367645, PubMed:20335357, PubMed:25655701, PubMed:28235200). Required for membrane fusion, but not for the initial adhesion between gametes (PubMed:18367645, PubMed:25655701, PubMed:28235200). Inserts (via its extracellular domain) into lipid membranes (in vitro) (PubMed:28235200). Probably initiates the fusion of gamete cell membranes by inserting its extracellular domain into the cell membrane of a female gamete (PubMed:28235200). Monomer. Homotrimer. Membrane contact and insertion (via its extracellular domain) into a lipid membrane probably triggers trimerization.

Also known as HAP2_CHLRE, HAP2, GCS1. During fertilization, required on male (minus) gametes for their fusion with female (plus) gametes (PubMed:18367645, PubMed:20335357, PubMed:25655701, PubMe ...

EXTERNAL LINKS

HAP2

Mutations

Mutation(s) distribution

Mutations table