FEATURES

FAMILY

SAM hydrolase / SAM-dependent halogenase family

DESCRIPTION

Also known as SALL_SALTO, salL. Involved in the biosynthesis of the proteosome inhibitor salinosporamide A (SalA). Catalyzes the halogenation of S-adenosyl-L-methionine (SAM) with chloride to generate 5'-chloro-5'-deoxyadenosine (5'-CIDA) and L-methionine. It can also use bromide and iodide, producing halogenated 5'-deoxyadenosine (5'-XDA) and L-methionine, however no halogenase activity is detected in the presence of fluoride. Homotrimer.

EXTERNAL LINKS

uniprot
enzyme classification

salL

Mutations

Mutation(s) distribution

Mutations table