FEATURES

FAMILY

DESCRIPTION

Also known as CAN8_HUMAN, CAPN8, NCL2. Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity). Monomer and homooligomer. Interacts with COPS1/GPS1, COPB1, EYA2, NME2, NME4 and TOMM70 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CAPN8

Mutations

Mutation(s) distribution

Mutations table