FEATURES

FAMILY

DESCRIPTION

Also known as CDUB1_CHLT2, cdu1. Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease possesses deubiquitinating and deneddylating activities (By similarity). Impairs ubiquitination and degradation of NF-kappa-B inhibitor alpha (NFKBIA), thereby preventing NF-kappa-B activation. Binds to host NFKBIA.

EXTERNAL LINKS

uniprot
enzyme classification

cdu1

Deubiquitinase and deneddylase Dub1

cdu1

Molecular Synopsis