FEATURES

FAMILY

DESCRIPTION

Also known as PRPC_ASPFC, mcsA. Component of the methylcitrate cycle that catalyzes the synthesis of (2S, 3S)-2-methylcitrate from propionyl-CoA and oxaloacetate. Plays an important role in detoxification of propionyl-CoA, an inhibitor of both primary and secondary metabolism. Has also citrate synthase activity using as substrates acetyl-CoA and oxaloacetate. Plays a key role in the estabishment of invasive pulmonary aspergillosis. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

mcsA

2-methylcitrate synthase, mitochondrial

Mutations

Mutation(s) distribution

Mutations table

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