FEATURES

FAMILY

DESCRIPTION

Also known as BDLP_NOSP7, Npun_R6513. Dynamin-related GTPase probably involved in membrane remodeling. Lipid and nucleotide-binding are thought to induce a large intramolecular rearrangement, leading to assembly on lipid bilayers and possible membrane curving. In the presence of the non-hydrolyzable GTP analog GMP-PNP self-assembles on a lipid bilayer; this does not stimulate subsequent GTPase activity. Does not bind lipids in the presence of GDP; perhaps GTP hydrolysis disrupts membrane-binding. Homodimer. Self-assembles in the presence of GMP-PNP and liposomes, and probably also in the presence of GTP.

EXTERNAL LINKS

uniprot
enzyme classification

Npun_R6513

Mutations

Mutation(s) distribution

Mutations table