FEATURES

FAMILY

SETD3 actin-histidine methyltransferase family

DESCRIPTION

Also known as SETD3_RHIFE, SETD3. Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73'. Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery. Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin. Interacts with MYOD1.

EXTERNAL LINKS

uniprot
enzyme classification

SETD3

Actin-histidine N-methyltransferase

SETD3

Molecular Synopsis