FEATURES

FAMILY

class-V pyridoxal-phosphate-dependent aminotransferase family

DESCRIPTION

Also known as ISCS_ECOLU, iscS. Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate. Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.

EXTERNAL LINKS

uniprot
enzyme classification

iscS

Cysteine desulfurase IscS

iscS

Molecular Synopsis