FEATURES

FAMILY

glutaminyl-peptide cyclotransferase family

DESCRIPTION

Also known as QPCT_IXOSC, Qptc. Responsible for the biosynthesis of pyroglutamyl peptides (PubMed:23770496, PubMed:24598748). Seems to have a preference for substrates with neutral or hydrophobic amino-acid residues at the second and third positions (PubMed:24598748). Shows activity towards the peptides [Gln-1]-corazonin, [Gln-1]-periviscerokinin and [Gln-1]-sulfakinin (PubMed:24598748).

EXTERNAL LINKS

uniprot
enzyme classification

Qptc

Glutaminyl-peptide cyclotransferase

Mutations

Mutation(s) distribution

Mutations table

Search Mutation