FEATURES

FAMILY

DESCRIPTION

Also known as PAFA_MYCBT, pafA. Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.

EXTERNAL LINKS

uniprot
enzyme classification

pafA

Pup--protein ligase

pafA

Molecular Synopsis