FEATURES

FAMILY

DESCRIPTION

Also known as CM3B_CONBU, CM3B. Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin potently blocks rNav1.4/SCN4A (Kd=0.34-3.6 nM), rNav1.2/SCN2A (Kd=13 nM), rNav1.3/SCN3A (Kd=200 nM), rNav1.1/SCN1A (Kd=360 nM), mNav1.6/SCN8A (IC(50)=1.8 uM), rNav1.5/SCN5A (IC(50)=9 uM), rNav1.6/SCN8A (IC(50)>30 uM) (PubMed:18950653, PubMed:21652775, PubMed:25632083, PubMed:23557677). It is noteworthy that the toxin is 50-fold more potent on mouse Nav1.6 than on rat Nav1.6 (PubMed:25632083). The block of SCN4A is very slowly reversible (PubMed:18950653).

EXTERNAL LINKS

uniprot
enzyme classification

CM3B

Mutations

Mutation(s) distribution

Mutations table