FEATURES

FAMILY

antibiotic biosynthesis monooxygenase family

DESCRIPTION

Also known as HDOX_BACAC, isdG. Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the biliverdin in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

isdG

Heme-degrading monooxygenase

isdG

Molecular Synopsis