FEATURES

FAMILY

DESCRIPTION

Also known as PNMT_THLFG, PNMT. N-methyltransferase with a substrate preference for (+-)-pavine, but also active with (R, S)-stylopine, (R, S)-scoulerine, (R, S)-tetrahydropalmatine, (R, S)-tetrahydropapaverine and (S)-reticuline (PubMed:19624470, PubMed:27573242). No activity with (R)-reticuline (PubMed:27573242). In the presence of a racemic mixture of tetrahydropapaverine (THP), one molecule of (S)-THP binds in a productive mode, while one molecule of (R)-THP is bound next to it in a non-productive mode (PubMed:27573242). The (R)-THP may inhibit the release of products from the enzyme when higher concentrations of the racemic substrate are added to the reaction (PubMed:27573242). Homodimer.

Also known as PNMT_THLFG, PNMT. N-methyltransferase with a substrate preference for (+-)-pavine, but also active with (R, S)-stylopine, (R, S)-scoulerine, (R, S)-tetrahydropalmatine, (R, S)-tetra ...

EXTERNAL LINKS

PNMT

Mutations

Mutation(s) distribution

Mutations table