FEATURES

FAMILY

NADH:flavin oxidoreductase/NADH oxidase family

DESCRIPTION

Also known as DBR2_ARTAN, DBR2, AAR. Involved in the biosynthesis of the antimalarial endoperoxide artemisinin (PubMed:18495659, PubMed:27488942). Catalyzes the double bond reduction of artemisinic aldehyde to produce (11R)-dihydroartemisinic aldehyde (PubMed:18495659). Also able to reduce 2-cyclohexen-1-one into cyclohexanone to a lesser extent (PubMed:18495659).

EXTERNAL LINKS

uniprot
enzyme classification

DBR2

Artemisinic aldehyde Delta(11(13)) reductase

Mutations

Mutation(s) distribution

Mutations table

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