FEATURES

FAMILY

DESCRIPTION

Also known as LINB_SPHJU, linB. Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. Has a broad substrate specificity since not only monochloroalkanes (C3 to C10) but also dichloroalkanes (> C3), bromoalkanes, and chlorinated aliphatic alcohols are good substrates (PubMed:9293022, PubMed:10100638). Shows almost no activity with 1, 2-dichloroethane, but very high activity with the brominated analog (PubMed:9293022). Is involved in the degradation of the important environmental pollutant gamma-hexachlorocyclohexane (gamma-HCH or lindane) as it also catalyzes conversion of 1, 3, 4, 6-tetrachloro-1, 4-cyclohexadiene (1, 4-TCDN) to 2, 5-dichloro-2, 5-cyclohexadiene-1, 4-diol (2, 5-DDOL) via the intermediate 2, 4, 5-trichloro-2, 5-cyclohexadiene-1-ol (2, 4, 5-DNOL) (PubMed:7691794). This degradation pathway allows S.japonicum UT26 to grow on gamma-HCH as the sole source of carbon and energy. Monomer.

EXTERNAL LINKS

linB

Haloalkane dehalogenase

linB

Molecular Synopsis