FEATURES

FAMILY

DESCRIPTION

Also known as CDNC_ECOM1, cdnC. CBASS (cyclic oligonucleotide-based antiphage signaling system) provides immunity against bacteriophage. The CD-NTase protein synthesizes cyclic nucleotides in response to infection; these serve as specific second messenger signals. The signals activate a diverse range of effectors, leading to bacterial cell death and thus abortive phage infection. A type III-C(AAA) CBASS system (PubMed:32839535)., Cyclic nucleotide synthase that upon activation catalyzes the synthesis of 2', 3', 3'-cyclic AMP-AMP-AMP (cAAA) as the major product, and c-di-AMP as a minor product. Binds ATP or AMP depending on its partner protein, and probably catalytic cycle., Protects E.coli strain JP313 against bacteriophage lambda cI- infection. When the cdnC-cap7-cap6-nucC operon is transformed into a susceptible strain it confers bacteriophage immunity. Mutations in the sensor (Cap7 also called HORMA) or effector proteins (CdnC, NucC) but not the disassembly protein (Cap6 also called Trip13) no longer confer immunity. The presence of the intact operon leads to culture collapse and cell death, which occurs before the phage has finished its replication cycle, thus protecting non-infected bacteria by aborting the phage infection and preventing its propagation. Forms complexes with Cap7 with 1:1 and 2:2 stoichimetry, and a 1:1:6 CdnC:Cap7:Cap6 complex.

EXTERNAL LINKS

cdnC

Cyclic AMP-AMP-AMP synthase

cdnC

Molecular Synopsis